First year high school student and occultist, Nene Yashiro summons "Hanako-san of the Toilet" to grant her romantic wishes. She ends up Hanako's spiritual assistant, helping him destroy supernatural beings and change rumors to balance the spirit and human worlds. Along the way, Nene learns about her connection to the spirit world and the dark secrets regarding Hanako's past.

Years ago, many magical "Artifacts" were stolen and scattered throughout the world. They fell into the hands of people who were not supposed to know of their existence. The Hoshisato family of magicians has special access to the Artifacts, and they take it upon themselves to return them to their rightful place. Despite her inexperience, Kana wishes to aid her parents, doing her best to improve. Meanwhile, her childhood friend Makoto has come to their mansion to study magic under her father's tutelage. Hatena is excited to see her friend again, only to be utterly disappointed when the person she thought to be a girl all these years turns out to be a boy. Before long, Makoto comes to know of the Artifacts. Unfazed, he continues to strive to fulfill his promises and stay true to why he learns magic - to ease the sadness of people around him and, most importantly, to become a person worthy of being Hatena's partner.

The show opens with a girl who yearns to be popular and liked in her school. She wishes she was in the "in-crowd", however, she goes about unnoticed in school everyday. The only girl who truly notices her is her best friend Thelma. For some strange reason though, Cassie feels like she is being followed by a man. This is only the beginning of her problem...

The fate of mankind is doomed in the early 21st century due to losing "purana," an essence of living force supporting all life forms. Not willing to witness the extinction of mankind, a vampire named Duo disclosed the secret of purana to humans, saving the latter from destruction. However, just like Prometheus in Greek mythology got punished for bringing fire to mankind, Duo is punished for breaking the taboo. The vampire sent to punish him is Zieg, Duo's best friend, or, more than the best friend.