The doctors prepare to open a new clinic but are apprehensive about a promise they made to each other regarding the event; Dr. Ross tends to a frizzle hen's eye problem; Dr. Blue is alarmed by a bulldog's burst mammary gland.

Dr. Ross goes to surgery when constipation becomes serious for a tegu lizard; Dr. Blue treats a boxer that can barely breathe; the doctors help a baby alpaca in distress and are given VIP access to a special event as a thank you.

A chicken is rushed to Dr. Ross after being attacked by a coyote; when a Great Dane mix has a seizure, Dr. Lavigne uncovers multiple issues; a surprise serenade at the clinic musically inspires Dr. Blue.

Dr. Lavigne performs a doggy nose job to help a pug with bad breathing problems; Dr. Blue urgently treats Hardtime, a dog who's facing hard times battling heart disease; an opossum with a traumatic injury needs Dr. Ross's help.

Birds of prey at the Renaissance Faire are in need of the West Nile vaccine; Piper the peppy dachshund is not so peppy; Dr. Lavigne performs surgery; Dr. Ross helps Tesla the tortoise with a fractured beak.

Dr. Lavigne does a not-so-routine surgery on a hermaphrodite dog that's both male and female; a bearded dragon battles a skin disease that Dr. Ross must treat before it causes serious problems; Dr. Blue manages work and a big family move.

Police rescue a turtle caught on fishing line, and it's up to Dr. Ross to unhook him; Dr. Blue waits for test results after performing dental surgery on a loveable dachshund; Dr. Lavigne gives a stray cat first-class treatment.