A 32-year-old man collapses and dies at his sister's home. The man had been feeling sick for a week prior to his collapse. Dr. G has no medical records to go on, as the man did not go to the doctor, but his external appearance indicates that he was in extremely poor health. Dr. G suspects that the man's self-neglect may have played a role in his death. A 49-year-old father is found dead in his kitchen with multiple stab wounds. The man's teenage son claims that his father stabbed himself to death, but the police suspect that the son was responsible. It's up to Dr. G to determine if the death was a suicide or a homicide.

An 18-year-old seemingly healthy athlete dies two days after being hospitalized with back pain and a mysterious rash. Dr. G suspects an infection, and is concerned that this case may have public health implications. A 49-year-old woman is found dead on her couch, covered with blood from a head wound. Blood on the stone hearth of the fireplace suggests that woman struck her head. Did she simply fall, or was she assaulted? It's up to Dr. G to find out.

A 28-year-old man inexplicably erupts into a violent rage during a cookout, and then collapses and dies. The man had schizophrenia, in addition to a lengthy medical history. Dr. G also considers the possibility that the man was fatally injured as his family struggled to bring him under control. With a long list of possibilities, Dr. G must let the body speak for itself as she searches for the answer. A 22-year-old pregnant woman collapses and dies after experiencing chest pains. Dr. G's colleague, Dr. Norma Jean Farley, is tasked with finding the cause of death. When the answer proves elusive, Dr. Farley reaches out to the woman's family, and discovers that the young mother had been keeping a deadly secret.

A 61-year-old man is found dead on his bed, his body covered with dog bites and scratches. Could the man have been fatally attacked by his own dog? It's up to Dr. G to find out. A four-month-old baby is found dead in her crib. With no overt clues, Dr. G fears that the cause of death may go undetermined.

A 52-year-old man is found dead in a motel parking lot. The man was reportedly ill when he checked into the motel two days prior, but Dr. G is also on the lookout for signs of foul play. A 45-year-old father is found dead at the base of his attic ladder. The man had been renovating the attic, making heat stroke and power tool electrocution possibilities. It's up to Dr. Joshua Stephany, Dr. G's youngest medical examiner, to piece together the details of this perplexing case.

A 25-year-old man falls ill soon after arriving in Orlando by plane, and his condition rapidly declines in the hospital. The man abruptly develops mysterious skin lesions, and dies within 18 hours. Fearing a public health emergency, the hospital calls Dr. G and requests an autopsy. A 49-year-old man answers a knock at his back door and is shot multiple times. With few clues as to the killer's identity, police launch a full-scale investigation as Dr. G searches the body for evidence.