In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly, and patient Jeffrey Goines, the son of a famous virus expert, who may hold the key to the mysterious rogue group, the Army of the 12 Monkeys, thought to be responsible for unleashing the killer disease.

Robert Neville is a scientist who was unable to stop the spread of the terrible virus that was incurable and man-made. Immune, Neville is now the last human survivor in what is left of New York City and perhaps the world. For three years, Neville has faithfully sent out daily radio messages, desperate to find any other survivors who might be out there. But he is not alone.

In this feature-length film combining footage from classic Warner Brothers cartoon shorts with newly animated bridging sequences, Daffy Duck, after having induced laughter in an ailing millionaire and forestalled the millionaire's death for a time (as chronicled in Daffy Dilly (1948), is the beneficiary for the deceased millionaire's assets. But the millionaire's will clearly stipulates that Daffy must use the money for the common good, by providing a service, and should Daffy think of pursuing selfish aims, the millionaire's ghost will "repossess" his millions by making them disappear from Earthly existence. Under the pretense of community service, Daffy opens an exorcism agency and employs Porky Pig, Sylvester Cat, and Bugs Bunny to track and eliminate ghosts, ghouls, and other monsters, while Daffy secretly schemes to use his learned "ghost-busting" talents to rid himself of the millionaire's nagging spirit.

Following World War III, four survivors at an desert military installation attempt to drive across the desolate wasteland of America to Albany, where they hope more survivors are living, using a specially built vehicles to protect themselves against the freakish weather, mutated plant and animal life, and other dangers encountered along the way.